Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | HTR7 | P34969 | 5/20 | 0.33 |
| ▸ | HTR6 | P50406 | 5/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 2/20 | 0.31 |
| ▸ | CTSC | P53634 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310533 | 0.89 | MAP4K1 (0.35) | HRH4MAP4K1EGFR | |
| SCHEMBL24309350 | 0.88 | HTR3A (0.33) | HTR7HTR6HTR2AHTR1A | |
| SCHEMBL24310427 | 0.87 | PLK1 (0.33) | MAP4K1 | |
| SCHEMBL24309872 | 0.87 | CCNA2 (0.40) | SLC2A1 | |
| SCHEMBL24310751 | 0.86 | MAP4K1 (0.34) | MAP4K1DRD2HTR2AHTR1AEGFR | |
| SCHEMBL24310284 | 0.85 | MAP4K1 (0.37) | HRH4MAP4K1DRD2HTR7HTR6 | |
| SCHEMBL29566991 | 0.83 | HTR1D (0.37) | HTR1DHTR1BHRH4MAP4K1DRD2 | |
| SCHEMBL26809817 | 0.83 | HTR1D (0.37) | HTR1DHTR1BHRH4MAP4K1DRD2 | |
| SCHEMBL24310753 | 0.83 | MAP4K1 (0.37) | MAP4K1EGFR | |
| SCHEMBL24310550 | 0.83 | LMNA (0.33) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |