SCHEMBL24310463

SCHEMBL24310463

Cc1nn(C)c(=O)c(-c2c(F)ccc(Cl)c2CCc2cccnc2)c1O

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.36
GRIN1 Q05586 1/20 0.35
GRIN2B Q13224 1/20 0.35
GPBAR1 Q8TDU6 4/20 0.35
MAPT P10636 3/20 0.35
P2RX7 Q99572 1/20 0.35
ALDH1A1 P00352 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
LMNA P02545 1/20 0.34
GRM2 Q14416 2/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
CCR9 P51686 1/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29582525 1.00 GAA (0.36) GAAGRIN1GRIN2BGPBAR1MAPT
SCHEMBL25201217 0.89 MAPT (0.34) MAPTLMNAKMT2A
SCHEMBL30389235 0.89 MAPT (0.34) MAPTLMNAKMT2A
SCHEMBL22031792 0.89 CASR (0.40) MAPTLMNAKMT2A
SCHEMBL22084636 0.86 LMNA (0.36) MAPTLMNAKMT2A
SCHEMBL22031854 0.85 CYP1A2 (0.38) MAPTP2RX7LMNA
SCHEMBL22085782 0.84 MAPT (0.37) MAPTP2RX7LMNAKMT2A
SCHEMBL22906297 0.83 LMNA (0.40) MAPTLMNAKMT2A
SCHEMBL25180883 0.83 GRIN2B (0.33) GAAGRIN1GRIN2BMAPTLMNA
SCHEMBL30388667 0.83 GRIN2B (0.33) GAAGRIN1GRIN2BMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3890487-B1 HERBICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2024-06-12 EP claimed
US-20230301300-A1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2023-09-28 US disclosed
US-20230301300-A1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2023-09-28 US disclosed
US-20220119353-A1 Herbicidal Compositions SYNGENTA PARTICIPATIONS AG (CH) 2022-04-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230301300-A1 HERBICIDAL COMPOSITIONS GMDS, DDT, AADAC GAA 687/4885GRIN1 1599/4885GRIN2B 1740/4885
US-20220119353-A1 Herbicidal Compositions DDT, HPD, PNPO GAA 736/4885GRIN1 2343/4885GRIN2B 2195/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.