SCHEMBL2431059

SCHEMBL2431059

Cc1c([N+](=O)[O-])cccc1C(F)(F)F

nearest known ligand 0.64

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.64
ALDH1A1 P00352 2/20 0.59
TSHR P16473 3/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
HSD17B10 Q99714 1/20 0.47
GPR35 Q9HC97 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
NPC1 O15118 2/20 0.44
MAPK1 P28482 2/20 0.44
MAPT P10636 1/20 0.44
PARP1 P09874 1/20 0.43
POLB P06746 1/20 0.42
NPSR1 Q6W5P4 1/20 0.41
GAA P10253 1/20 0.41
RAB9A P51151 1/20 0.41
LMNA P02545 1/20 0.41
KMT2A Q03164 1/20 0.41
GLA P06280 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30800293 1.00 TDP1 (0.64) TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10
SCHEMBL3272898 0.83 ALDH1A1 (0.49) TDP1ALDH1A1TSHRSMN1; SMN2MAPT
SCHEMBL15034656 0.83 TDP1 (0.67) TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10
SCHEMBL27873825 0.81 TDP1 (0.64) TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10
SCHEMBL17845330 0.81 ALDH1A1 (0.49) TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10
SCHEMBL31122003 0.81 ALDH1A1 (0.49) TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10
SCHEMBL30627320 0.80 ALDH1A1 (0.50) TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10
SCHEMBL1999849 0.80 ALDH1A1 (0.50) TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10
SCHEMBL472112 0.80 TDP1 (1.00) TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10
SCHEMBL1459395 0.79 TSHR (0.53) TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117143519-B High-temperature-resistant butterfly valve and production process thereof 迪力阀门科技有限公司 2025-05-02 CN claimed
CN-117143519-A High-temperature-resistant butterfly valve and production process thereof 迪力阀门科技有限公司 2023-12-01 CN claimed
CN-102491906-B Synthetic method for 2-methyl-3-trifluoromethyl phenylamine QILU ANIMAL HEALTH PRODUCTS CO 2013-10-23 CN claimed
CN-102558059-A Brand-new indazole compound and its synthetic method TIANJIN SPHINX PHARMACEUTICAL RES DEV CO LTD 2012-07-11 CN claimed
CN-102491906-A Synthetic method for 2-methyl-3-trifluoromethyl phenylamine QILU ANIMAL HEALTH PRODUCTS CO 2012-06-13 CN claimed
US-4831193-A Synthesis of 3-amino-2-methylbenzotrifluoride SCHERING CORPORATION (US) 1989-05-16 US claimed
CN-1030073-A The novel synthesis of 3-amino-2-methyl phenylfluoroform SCHERING CORP (US) 1989-01-04 CN claimed
WO-1988010247-A1 NOVEL SYNTHESIS OF 3-AMINO-2-METHYLBENZOTRIFLUORIDE SCHERING CORPORATION (US) 1988-12-29 WO claimed
EP-0295674-A1 Novel synthesis of 3-amino-2-methylbenzotrifluoride SCHERING CORPORATION (US) 1988-12-21 EP claimed
JP-7017921-A None JP disclosed
JP-6239808-A None JP disclosed
EP-4743078-A2 APOL1 INHIBITORS AND METHODS OF USE Maze Therapeutics, Inc. (US) 2026-05-20 EP disclosed
EP-4724436-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING Remix Therapeutics Inc. (US) 2026-04-15 EP disclosed
EP-4724438-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING Remix Therapeutics Inc. (US) 2026-04-15 EP disclosed
US-4752645-A Benzazepine derivatives E. R. SQUIBB & SONS, INC. (US) 1988-06-21 US disclosed
US-4748239-A VASODILATORS E. R. SQUIBB & SONS, INC. (US) 1988-05-31 US disclosed
EP-0229329-A1 Benzazepine derivatives E.R. Squibb & Sons, Inc. (US) 1987-07-22 EP disclosed
US-4209464-A Novel synthesis of 3-amino-2-methylbenzotrifluoride from N-(2-X-5-trifluoromethylphenyl)-S,S-dimethylsulfimide SCHERING CORPORATION (US) 1980-06-24 US disclosed
US-4172095-A Novel synthesis of 3-amino-2-methylbenzotrifluoride and the intermediates thereof SCHERING CORPORATION (US) 1979-10-23 US disclosed
US-4132737-A ENZYME INHIBITORS ELI LILLY AND COMPANY (US) 1979-01-02 US disclosed