Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431059 | 1.00 | TDP1 (0.64) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL3272898 | 0.83 | ALDH1A1 (0.49) | TDP1ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL15034656 | 0.83 | TDP1 (0.67) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL27873825 | 0.81 | TDP1 (0.64) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL17845330 | 0.81 | ALDH1A1 (0.49) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL31122003 | 0.81 | ALDH1A1 (0.49) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL30627320 | 0.80 | ALDH1A1 (0.50) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL1999849 | 0.80 | ALDH1A1 (0.50) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL472112 | 0.80 | TDP1 (1.00) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL1459395 | 0.79 | TSHR (0.53) | TDP1ALDH1A1TSHRSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122055363-A | Compounds and methods for modulating splicing | 雷密克斯医疗公司 | 2026-05-15 | — | — | CN | disclosed |
| EP-4558504-A1 | CBL-B INHIBITORS AND METHODS OF USES THEREOF | Insilico Medicine IP Limited (HK) | 2025-05-28 | — | — | EP | disclosed |
| CN-119630662-A | CBL-B inhibitors and methods of use thereof | 英矽智能科技知识产权有限公司 | 2025-03-14 | — | — | CN | disclosed |
| WO-2024131939-A1 | CBL-B INHIBITORS AND METHODS OF USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2024-06-27 | — | — | WO | disclosed |
| WO-2024017201-A1 | CBL-B INHIBITORS AND METHODS OF USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2024-01-25 | — | — | WO | disclosed |