Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.52 |
| ▸ | RBP4 | P02753 | 1/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310337 | 0.88 | KDM4C (0.50) | KDM4CKDM5AKDM5BRBP4KLKB1 | |
| SCHEMBL16690901 | 0.84 | RBP4 (0.54) | KDM4CKDM5AKDM5BRBP4KLKB1 | |
| SCHEMBL3688462 | 0.84 | KDM4C (0.57) | KDM4CKDM5AKDM5BRBP4KLKB1 | |
| SCHEMBL23188881 | 0.83 | RBP4 (0.48) | KDM4CKDM5AKDM5BRBP4KLKB1 | |
| SCHEMBL1129548 | 0.83 | KLKB1 (0.47) | KDM4CKDM5AKDM5BRBP4KLKB1 | |
| SCHEMBL15964744 | 0.81 | RBP4 (0.54) | KDM4CKDM5AKDM5BRBP4KLKB1 | |
| SCHEMBL9248509 | 0.81 | LMNA (0.60) | KDM4CKDM5AKDM5BRBP4KLKB1 | |
| SCHEMBL18367381 | 0.81 | CDK5 (0.53) | KDM4CKDM5AKDM5BRBP4KLKB1 | |
| SCHEMBL16689551 | 0.81 | RBP4 (0.51) | KDM4CKDM5AKDM5BRBP4KLKB1 | |
| SCHEMBL18377475 | 0.81 | KLKB1 (0.56) | KDM4CKDM5AKDM5BRBP4KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3978492-A1 | BICYCLIC COMPOUND AS RIP-1 KINASE INHIBITOR AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2022-04-06 | — | — | EP | disclosed |