Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.54 |
| ▸ | ADA | P00813 | 3/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.50 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3688462 | 0.87 | KDM4C (0.57) | RBP4KDM4CKDM5AKDM5BKLKB1 | |
| SCHEMBL15965385 | 0.84 | KLKB1 (0.49) | RBP4KLKB1CYP19A1 | |
| SCHEMBL16690901 | 0.84 | RBP4 (0.54) | RBP4KDM4CKDM5AKDM5BKLKB1 | |
| SCHEMBL15965384 | 0.83 | KDM4C (0.57) | ADAKDM4CNPC1RAB9A | |
| SCHEMBL9714098 | 0.82 | LMNA (0.50) | RBP4ADAKDM4CKDM5AKDM5B | |
| SCHEMBL24310642 | 0.81 | KDM4C (0.52) | RBP4KDM4CKDM5AKDM5BKLKB1 | |
| SCHEMBL31591084 | 0.81 | USP30 (0.40) | RBP4ADAKDM4CKDM5AKDM5B | |
| SCHEMBL16689551 | 0.80 | RBP4 (0.51) | RBP4KDM4CKDM5AKDM5BKLKB1 | |
| SCHEMBL20344493 | 0.80 | RBP4 (0.51) | RBP4KDM4CKDM5AKDM5BKLKB1 | |
| SCHEMBL18367381 | 0.80 | CDK5 (0.53) | RBP4KDM4CKDM5AKDM5BKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108314654-A | A kind of intermediate and its preparation method and application being used to prepare Medetomidine | 山东百诺医药股份有限公司 | 2018-07-24 | — | — | CN | claimed |
| EP-3816163-A1 | CELL NECROSIS INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CN) | 2021-05-05 | — | — | EP | disclosed |
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| CN-110577519-A | N- ((hetero) arylmethyl) -heteroaryl-carboxamide compounds as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2019-12-17 | — | — | CN | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| CN-105829317-B | Imidazopyrazines ketone derivatives | 默克专利股份公司 | 2019-03-29 | — | — | CN | disclosed |
| CN-108368089-A | Novel Compounds | 特殊治疗有限公司 | 2018-08-03 | — | — | CN | disclosed |
| CN-108314654-A | A kind of intermediate and its preparation method and application being used to prepare Medetomidine | 山东百诺医药股份有限公司 | 2018-07-24 | — | — | CN | disclosed |
| US-9718826-B2 | Imidazopyrazinone derivatives | MERCK PATENT GMBH (DE) | 2017-08-01 | — | — | US | disclosed |
| EP-3140295-A1 | HETEROCYCLYL-BUTANAMIDE DERIVATIVES | Merck Patent GmbH (DE) | 2017-03-15 | — | — | EP | disclosed |
| US-20170002010-A1 | IMIDAZOPYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-01-05 | — | — | US | disclosed |
| US-20170002010-A1 | IMIDAZOPYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-01-05 | — | — | US | disclosed |
| EP-3087076-A1 | IMIDAZOPYRAZINONE DERIVATIVES | Merck Patent GmbH (DE) | 2016-11-02 | — | — | EP | disclosed |
| CN-105829317-A | Imidazopyrazinone derivatives | 默克专利股份公司 | 2016-08-03 | — | — | CN | disclosed |
| WO-2015169421-A1 | HETEROCYCLYL-BUTANAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-11-12 | — | — | WO | disclosed |
| WO-2015096884-A1 | IMIDAZOPYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-07-02 | — | — | WO | disclosed |
| WO-2015096884-A1 | IMIDAZOPYRAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-07-02 | — | — | WO | disclosed |
| WO-2014125444-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170002010-A1 | IMIDAZOPYRAZINONE DERIVATIVES | IRAK1, IRAK3, TNKS | RBP4 2910/4885ADA 3453/4885KDM4C 1105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.