Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | ULK1 | O75385 | 2/20 | 0.34 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | LOX | P28300 | 2/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310792 | 0.91 | F2 (0.38) | F10F2NR1H2NR1H3FGFR1 | |
| SCHEMBL24310347 | 0.86 | GPR39 (0.39) | NTRK1 | |
| SCHEMBL24310126 | 0.85 | AURKA (0.36) | F10F2LOXL2ENPP2 | |
| SCHEMBL29567200 | 0.83 | F10 (0.43) | F10F2NR1H2NR1H3FGFR1 | |
| SCHEMBL24310795 | 0.83 | F10 (0.43) | F10F2NR1H2NR1H3FGFR1 | |
| SCHEMBL24309553 | 0.82 | MAP4K1 (0.31) | — | |
| SCHEMBL24310550 | 0.82 | LMNA (0.33) | NTRK1ENPP2 | |
| SCHEMBL24310563 | 0.82 | HPGD (0.31) | F2 | |
| SCHEMBL24309565 | 0.81 | PPARG (0.34) | F10F2ENPP2PTK2 | |
| SCHEMBL24309575 | 0.80 | NPC1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |