Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310788 | 0.88 | P2RX7 (0.34) | AURKAAURKBKDR | |
| SCHEMBL24310126 | 0.88 | AURKA (0.36) | LMNAMAP4K1ENPP2AURKAAURKB | |
| SCHEMBL24310347 | 0.84 | GPR39 (0.39) | LMNATDP1L3MBTL1AURKAAURKB | |
| SCHEMBL29566982 | 0.84 | ACLY (0.38) | KDR | |
| SCHEMBL24310549 | 0.84 | ACLY (0.38) | KDR | |
| SCHEMBL24309954 | 0.83 | HTR1D (0.36) | MAP4K1 | |
| SCHEMBL24309350 | 0.83 | HTR3A (0.33) | — | |
| SCHEMBL24310563 | 0.82 | HPGD (0.31) | — | |
| SCHEMBL24310796 | 0.82 | F10 (0.43) | ENPP2NTRK1 | |
| SCHEMBL24310211 | 0.81 | PTK2 (0.35) | MAP4K1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |