Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24352758 | 0.80 | KMT2A (0.41) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL28608364 | 0.80 | ALDH1A1 (0.40) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL28617506 | 0.77 | ALDH1A1 (0.45) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL12228113 | 0.74 | SMN1; SMN2 (0.63) | KMT2ASMN1; SMN2USP2MEN1ADRB2 | |
| SCHEMBL20746810 | 0.74 | USP2 (0.40) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL14092684 | 0.73 | KMT2A (0.38) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL4634682 | 0.73 | USP2 (0.43) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL3176857 | 0.73 | ALDH1A1 (0.47) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL10603631 | 0.72 | POLB (0.44) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL28606323 | 0.72 | LMNA (0.44) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784666-B1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2022-03-16 | — | — | EP | disclosed |