Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24314307 | 0.90 | RAB9A (0.45) | HDAC6NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL24313744 | 0.88 | HDAC6 (0.40) | HDAC6NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL26008098 | 0.86 | SLC16A3 (0.42) | NPC1RAB9ASMN1; SMN2TP53ACKR3 | |
| SCHEMBL24313789 | 0.85 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2TP53RXFP1 | |
| SCHEMBL22601061 | 0.84 | CHRNA7 (0.40) | HDAC6NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL22601047 | 0.84 | ACKR3 (0.37) | NPC1RAB9ASMN1; SMN2TP53ACKR3 | |
| SCHEMBL22601033 | 0.84 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL22601146 | 0.84 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL22600839 | 0.83 | RAB9A (0.41) | HDAC6NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL24313793 | 0.83 | ALDH1A1 (0.42) | HDAC6NPC1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |