Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.54 |
| ▸ | CA2 | P00918 | 4/20 | 0.54 |
| ▸ | CA9 | Q16790 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | TRIM24 | O15164 | 6/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.45 |
| ▸ | QDPR | P09417 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29587540 | 1.00 | CA12 (0.54) | CA12CA2CA9PKMCA1 | |
| SCHEMBL31525337 | 0.90 | CA2 (0.49) | CA12CA2CA9PKMCA1 | |
| SCHEMBL31525435 | 0.86 | PKM (0.49) | CA12CA2CA9PKMCA1 | |
| SCHEMBL31525738 | 0.84 | CA2 (0.47) | CA12CA2CA9PKMCA1 | |
| SCHEMBL22588095 | 0.83 | CA12 (0.49) | CA12CA2CA9PKMCA1 | |
| SCHEMBL11398247 | 0.81 | PKM (0.50) | CA12CA2CA9PKMCA1 | |
| SCHEMBL28022935 | 0.81 | QDPR (0.48) | CA12CA2CA9PKMCA1 | |
| SCHEMBL28022936 | 0.81 | QDPR (0.48) | CA12CA2CA9PKMCA1 | |
| SCHEMBL31525503 | 0.80 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL31525797 | 0.79 | TRIM24 (0.50) | TRIM24BRPF1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |