Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29587472 | 0.84 | ERN1 (0.36) | DRD1MAT2APDE4BPDE4APDE4C | |
| SCHEMBL24313734 | 0.84 | ERN1 (0.36) | DRD1MAT2APDE4BPDE4APDE4C | |
| SCHEMBL22103530 | 0.81 | ERN1 (0.39) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL24439732 | 0.80 | ESR2 (0.31) | — | |
| SCHEMBL22093032 | 0.78 | PDE4D (0.34) | MAT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL22093118 | 0.77 | PDE4A (0.33) | MAT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL22093060 | 0.74 | SLC6A3 (0.39) | MAT2APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL16268577 | 0.74 | DRD1 (0.34) | DRD1 | |
| SCHEMBL24313611 | 0.72 | ESR2 (0.36) | — | |
| SCHEMBL14302791 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |