Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.63 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | BAX | Q07812 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43037 | 0.91 | KCNA3 (0.52) | LTA4H | |
| SCHEMBL12926336 | 0.91 | MMP2 (0.51) | LTA4HPLA2G2ATSHRCYP1A2CYP2C9 | |
| SCHEMBL13696303 | 0.86 | LTA4H (0.67) | LTA4HPLA2G2ATSHRSMN1; SMN2NR1H2 | |
| Anisole SCHEMBL27689359 | 0.84 | CA4 (0.64) | LTA4HTSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3589633 | 0.83 | NQO1 (0.50) | LTA4HTSHRCYP2C9KDRMMP2 | |
| SCHEMBL2130060 | 0.83 | LSS (0.52) | LTA4HSMN1; SMN2 | |
| SCHEMBL27682382 | 0.82 | KCNA3 (0.48) | LTA4H | |
| SCHEMBL11696618 | 0.81 | LTA4H (0.68) | LTA4HPLA2G2ATSHRCYP1A2CYP2C9 | |
| SCHEMBL12772058 | 0.79 | LTA4H (0.64) | LTA4HCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL18319953 | 0.79 | CA1 (0.55) | TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |