Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469835 | 1.00 | ALDH1A1 (0.41) | ALDH1A1USP2GAAPKMHPGD | |
| SCHEMBL19122117 | 0.86 | ALDH1A1 (0.45) | ALDH1A1GAALMNATSHRMAPT | |
| SCHEMBL24313766 | 0.81 | TAS1R3 (0.47) | ALDH1A1USP2GAAPKMHPGD | |
| SCHEMBL23130388 | 0.81 | MAPT (0.54) | ALDH1A1GAALMNATSHRTP53 | |
| SCHEMBL20459373 | 0.81 | ALDH1A1 (0.51) | ALDH1A1GAALMNATP53MAPT | |
| SCHEMBL18713469 | 0.79 | MAPT (0.45) | ALDH1A1USP2GAAPKMHPGD | |
| SCHEMBL18713700 | 0.79 | KDM1A (0.45) | ALDH1A1USP2GAAPKMHPGD | |
| SCHEMBL19965694 | 0.77 | LMNA (0.47) | ALDH1A1USP2GAAPKMHPGD | |
| SCHEMBL10138860 | 0.77 | GAA (0.59) | ALDH1A1USP2GAAPKMHPGD | |
| SCHEMBL18713475 | 0.77 | HTT (0.49) | ALDH1A1USP2GAAPKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |