Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741127 | 0.89 | ALDH1A1 (0.59) | TSHRALDH1A1SMN1; SMN2ALPLKMT2A | |
| SCHEMBL10638959 | 0.86 | ALDH1A1 (0.46) | TSHRALDH1A1SMN1; SMN2TRPV4GAA | |
| SCHEMBL22587940 | 0.85 | CA1 (0.50) | TSHRALDH1A1SMN1; SMN2ALPLKMT2A | |
| SCHEMBL18713469 | 0.78 | MAPT (0.45) | TSHRALDH1A1SMN1; SMN2KMT2AGAA | |
| SCHEMBL7870540 | 0.78 | TSHR (0.58) | TSHRALDH1A1SMN1; SMN2ALPLKMT2A | |
| SCHEMBL2703971 | 0.78 | TSHR (0.62) | TSHRALDH1A1SMN1; SMN2ALPLKMT2A | |
| SCHEMBL34468880 | 0.78 | TSHR (0.58) | TSHRALDH1A1SMN1; SMN2ALPLKMT2A | |
| SCHEMBL29959795 | 0.78 | TSHR (0.58) | TSHRALDH1A1SMN1; SMN2ALPLKMT2A | |
| SCHEMBL21609096 | 0.76 | TRPV4 (0.50) | TSHRALDH1A1ALPLKMT2ATRPV4 | |
| SCHEMBL2701151 | 0.76 | GAA (0.58) | TSHRALDH1A1SMN1; SMN2KMT2ATRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |