Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7870540 | 1.00 | TSHR (0.58) | TSHRMEN1KMT2APOLBMAPK1 | |
| SCHEMBL25045969 | 0.86 | TRPV4 (0.63) | TSHRMEN1KMT2APOLBMAPK1 | |
| SCHEMBL34468880 | 0.83 | TSHR (0.58) | TSHRMEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL2703971 | 0.83 | TSHR (0.62) | TSHRKMT2AL3MBTL1SMN1; SMN2NPSR1 | |
| SCHEMBL29469925 | 0.83 | MEN1 (0.58) | TSHRMEN1KMT2APOLBMAPK1 | |
| SCHEMBL2701151 | 0.81 | GAA (0.58) | TSHRMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL21609096 | 0.81 | TRPV4 (0.50) | TSHRMEN1KMT2APOLBMAPK1 | |
| SCHEMBL24314192 | 0.81 | TRPV4 (0.50) | TSHRMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL12325147 | 0.81 | KDM4E (0.51) | TSHRMEN1KMT2APOLBMAPK1 | |
| SCHEMBL739940 | 0.80 | KMT2A (0.60) | TSHRMEN1KMT2APOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230000827-A1 | INHIBITORS OF HSP70 PROTEIN | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2023-01-05 | — | — | US | disclosed |
| EP-4061363-A1 | INHIBITORS OF HSP70 PROTEIN | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2022-09-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230000827-A1 | INHIBITORS OF HSP70 PROTEIN | HSPBP1, HSPH1, HSPA2 | TSHR 4175/4885MEN1 4654/4885KMT2A 4117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.