SCHEMBL24313774

SCHEMBL24313774

COc1ccc(C2CC2)cc1S(=O)(=O)NC(=O)c1cc2c(F)cc(C3CC3)cc2o1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRIM24 O15164 6/20 0.41
BRPF1 P55201 1/20 0.41
KAT7 O95251 1/20 0.38
KAT6B Q8WYB5 1/20 0.38
KAT6A Q92794 1/20 0.38
KAT5 Q92993 1/20 0.38
KAT8 Q9H7Z6 1/20 0.38
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
ALDH1A1 P00352 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
KDM4E B2RXH2 1/20 0.37
MAPT P10636 1/20 0.37
MCHR1 Q99705 3/20 0.37
KCNH2 Q12809 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
HTT P42858 1/20 0.35
LMNA P02545 2/20 0.35
GAA P10253 1/20 0.35
ALOX12 P18054 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29587808 0.91 ALDH1A1 (0.43) TRIM24BRPF1KMT2AMEN1ALDH1A1
SCHEMBL24314184 0.91 ALDH1A1 (0.43) TRIM24BRPF1KMT2AMEN1ALDH1A1
SCHEMBL24314247 0.90 MEN1 (0.36) TRIM24KAT7KAT6BKAT6AKAT5
SCHEMBL24313810 0.89 MCHR1 (0.37) TRIM24BRPF1KMT2AMEN1ALDH1A1
SCHEMBL24333741 0.88 TRIM24 (0.41) TRIM24BRPF1KAT7KAT6BKAT6A
SCHEMBL24314237 0.84 MRGPRX1 (0.38) KAT6AKMT2AMEN1L3MBTL1MCHR1
SCHEMBL24313699 0.82 SCN9A (0.35) KAT6AALDH1A1SMN1; SMN2HTTLMNA
SCHEMBL29587622 0.82 SCN9A (0.35) KAT6AALDH1A1SMN1; SMN2HTTLMNA
SCHEMBL24313760 0.82 SCN9A (0.35) KMT2AMEN1ALDH1A1L3MBTL1LMNA
SCHEMBL24313805 0.82 ALDH1A1 (0.34) KMT2AMEN1ALDH1A1L3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4229045-B1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER BROAD INST INC (US) 2025-11-12 EP claimed
EP-4229045-A1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER The Broad Institute Inc. (US) 2023-08-23 EP claimed
WO-2022081842-A1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER THE BROAD INSTITUTE, INC. (US) 2022-04-21 WO claimed
EP-4229045-A1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER The Broad Institute Inc. (US) 2023-08-23 EP disclosed
WO-2022081842-A1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER THE BROAD INSTITUTE, INC. (US) 2022-04-21 WO disclosed
WO-2022081842-A1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER THE BROAD INSTITUTE, INC. (US) 2022-04-21 WO disclosed