Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.38 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ASAH1 | Q13510 | 4/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24314214 | 0.89 | NPC1 (0.42) | NPC1RAB9AHSD11B1ALDH1A1MAPT | |
| SCHEMBL24313721 | 0.85 | PIM1 (0.49) | KMT2AALDH1A1MAPTL3MBTL1MAPK1 | |
| SCHEMBL22601061 | 0.85 | CHRNA7 (0.40) | NPC1RAB9AALDH1A1TSHRMIF | |
| SCHEMBL22601033 | 0.85 | NPC1 (0.51) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL24313789 | 0.84 | NPC1 (0.43) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL22600839 | 0.84 | RAB9A (0.41) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL24314307 | 0.84 | RAB9A (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL24313970 | 0.84 | ALDH1A1 (0.40) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL22601146 | 0.82 | NPC1 (0.39) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL24314221 | 0.82 | DRD3 (0.36) | NPC1RAB9AALDH1A1TSHRMIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |