Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | F7 | P08709 | 3/20 | 0.40 |
| ▸ | F3 | P13726 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22588031 | 0.84 | GAA (0.46) | GAALMNAMAPK1MEN1KMT2A | |
| SCHEMBL22588102 | 0.84 | GAA (0.46) | GAALMNAMAPK1MEN1KMT2A | |
| SCHEMBL22588366 | 0.84 | ALDH1A1 (0.42) | GAALMNAMAPK1ALPLMEN1 | |
| SCHEMBL22587733 | 0.83 | GAA (0.44) | GAALMNAMAPK1MEN1KMT2A | |
| SCHEMBL22588238 | 0.82 | GAA (0.43) | GAALMNAMAPK1MEN1KMT2A | |
| SCHEMBL24333686 | 0.81 | GAA (0.41) | GAALMNAMAPK1MEN1KMT2A | |
| SCHEMBL31723078 | 0.81 | ALDH1A1 (0.43) | LMNAALDH1A1THRBMAPT | |
| SCHEMBL24334306 | 0.81 | GAA (0.42) | GAALMNAMAPK1MEN1KMT2A | |
| SCHEMBL24334232 | 0.81 | NPC1 (0.46) | GAALMNAMAPK1MEN1KMT2A | |
| SCHEMBL24313655 | 0.80 | BCAT1 (0.53) | GAALMNAMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |