Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 10/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24314189 | 0.85 | PDE4A (0.39) | HTR2CHTR2BPDE4ACSNK2A1PDE4B | |
| SCHEMBL13678369 | 0.80 | CSNK2A1 (0.51) | HTR2CHTR2BPDE4ACSNK2A1KMO | |
| SCHEMBL13450374 | 0.78 | PDE4A (0.40) | HTR2CHTR2BPDE4APDE4BNPSR1 | |
| SCHEMBL31371799 | 0.78 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DNPSR1 | |
| SCHEMBL29469803 | 0.77 | HTR2C (0.40) | HTR2CHTR2BPDE4ACSNK2A1PDE4B | |
| SCHEMBL24313936 | 0.77 | HTR2C (0.40) | HTR2CHTR2BPDE4ACSNK2A1PDE4B | |
| SCHEMBL13499052 | 0.77 | CSNK2A1 (0.55) | HTR2CHTR2BPDE4ACSNK2A1KMO | |
| SCHEMBL13678364 | 0.77 | XDH (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24313723 | 0.75 | PDE4B (0.38) | HTR2CHTR2BPDE4AKMOPDE4B | |
| SCHEMBL20064209 | 0.75 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |