Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 4/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313917 | 0.86 | PDE4B (0.38) | PDE4BPDE4APDE4CPDE4DRIPK1 | |
| SCHEMBL24314212 | 0.81 | ACACB (0.39) | ACACB | |
| SCHEMBL13678313 | 0.81 | KMO (0.47) | PDE4BPDE4APDE4CPDE4DKMO | |
| SCHEMBL16852267 | 0.79 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DRIPK1 | |
| SCHEMBL13678365 | 0.78 | XDH (0.48) | PDE4B | |
| SCHEMBL18120363 | 0.78 | TRPV1 (0.45) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL24313901 | 0.78 | DHFR (0.44) | PDE4BPDE4APDE4CPDE4DRIPK1 | |
| SCHEMBL11951596 | 0.78 | ACACB (0.45) | PDE4BPDE4APDE4CPDE4DRIPK1 | |
| SCHEMBL1438963 | 0.78 | NPC1 (0.50) | PDE4BPDE4APDE4CPDE4DRIPK1 | |
| SCHEMBL24314286 | 0.75 | HTR2C (0.38) | PDE4BPDE4APDE4CPDE4DKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |