SCHEMBL24315366

SCHEMBL24315366

Fc1cccc(-c2ccccc2Cl)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.58
CLK4 Q9HAZ1 1/20 0.45
STK10 O94804 1/20 0.44
SLK Q9H2G2 1/20 0.44
PTGS2 P35354 1/20 0.44
TAAR1 Q96RJ0 2/20 0.44
ESR2 Q92731 1/20 0.44
HSD11B1 P28845 1/20 0.44
PDK2 Q15119 2/20 0.42
AR P10275 1/20 0.42
MAOB P27338 1/20 0.42
ALOX5AP P20292 1/20 0.42
FEN1 P39748 1/20 0.42
SCN9A Q15858 1/20 0.42
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
HPGD P15428 1/20 0.41
MAPK1 P28482 1/20 0.41
CASP3 P42574 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29628996 0.84 CYP2A6 (0.71) CYP2A6HSD11B1PDK2ARMAOB
SCHEMBL9479255 0.84 CYP2A6 (0.71) CYP2A6HSD11B1PDK2ARMAOB
SCHEMBL31067072 0.83 TAAR1 (0.44) CLK4TAAR1ESR2HSD11B1PDK2
SCHEMBL31067182 0.83 ABL1 (0.44) CLK4TAAR1ESR2MEN1KMT2A
SCHEMBL28100186 0.83 CYP2A6 (0.56) CYP2A6HSD11B1PDK2ARMAOB
SCHEMBL29287261 0.81 PTGS2 (0.46) CYP2A6PTGS2TAAR1ESR2HSD11B1
SCHEMBL31168142 0.80 HTT (0.49) CLK4TAAR1ESR2PDK2MAOB
SCHEMBL19503242 0.80 HTT (0.49) CLK4TAAR1ESR2PDK2MAOB
SCHEMBL6132074 0.79 PIK3CA (0.47) PTGS2KMT2A
SCHEMBL780417 0.78 PTPRC (0.50) CLK4TAAR1ESR2PDK2MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3619196-B1 2-{[2-(PHENYLOXYMETHYL)PYRIDIN-5-YL]OXY}-ETHANAMIN-DERIVATIVES AND RELATED COMPOUNDS AS PESTICIDES E.G. FOR CROP PROTECTION BAYER CROPSCIENCE AG (DE) 2022-03-30 EP disclosed
CN-104754942-A Use of substituted benzodiazepine ketones and benzazepine ketones or their salts as active substances against abiotic plant stress BAYER CROPSCIENCE AG 2015-07-01 CN disclosed
CN-1051311-C N-heteroaryl-n'-phenylurea derivatives, their production and use NIHON NOHYAKU CO LTD (JP) 2000-04-12 CN disclosed
CN-1100417-A N-heteroaryl-n'-phenylurea derivatives, their production and use NIHON NOHYAKU CO LTD (JP) 1995-03-22 CN disclosed