Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26620818 | 0.87 | TSHR (0.45) | TSHRSSTR3KDM4ELMNAALDH1A1 | |
| SCHEMBL6202521 | 0.80 | KDM4E (0.52) | TSHRKDM4EALDH1A1 | |
| SCHEMBL31613890 | 0.78 | KDM4E (0.45) | TSHRKDM4EALDH1A1 | |
| SCHEMBL27010653 | 0.76 | TRPV3 (0.39) | TSHRSSTR3KDM4EALDH1A1 | |
| SCHEMBL27010638 | 0.76 | MAOA (0.52) | TSHRALDH1A1 | |
| SCHEMBL27010655 | 0.75 | ALDH1A1 (0.39) | TSHRSSTR3KDM4ELMNAALDH1A1 | |
| SCHEMBL19865668 | 0.74 | ADORA2A (0.39) | KDM4ELMNA | |
| SCHEMBL31505955 | 0.74 | CD274 (0.47) | — | |
| SCHEMBL26996063 | 0.74 | CD274 (0.47) | — | |
| Hydrochloric Acid SCHEMBL31506100 | 0.72 | CD274 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |