Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 17/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.38 |
| ▸ | QDPR | P09417 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316420 | 0.82 | MAOB (0.45) | CSF1R | |
| SCHEMBL21327653 | 0.82 | CSF1R (0.54) | CSF1RNTRK1 | |
| SCHEMBL24316985 | 0.81 | MRGPRX4 (0.49) | CSF1R | |
| SCHEMBL24316419 | 0.80 | PDGFRB (0.49) | — | |
| SCHEMBL29539254 | 0.78 | EGFR (0.42) | CSF1RKDM5AKDM4CKDM5BNTRK1 | |
| SCHEMBL24316790 | 0.78 | EGFR (0.42) | CSF1RKDM5AKDM4CKDM5BNTRK1 | |
| SCHEMBL24316988 | 0.77 | CHRM4 (0.41) | CSF1R | |
| SCHEMBL27174564 | 0.74 | ESR2 (0.42) | KDM5AKDM4CKDM5B | |
| SCHEMBL24316987 | 0.73 | DHODH (0.38) | CSF1R | |
| SCHEMBL29859010 | 0.73 | CSF1R (0.62) | CSF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057895-A1 | HETEROAROMATIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |