Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21362951 | 0.85 | KCNH2 (0.37) | KMT2AHTR1AHRH3KCNH2MEN1 | |
| SCHEMBL22436028 | 0.79 | NOTUM (0.38) | KMT2AP2RY1HTR1AHRH3KCNH2 | |
| SCHEMBL24316040 | 0.79 | MAOA (0.53) | KMT2AADRA2AADRA2BADRA2CSLC6A2 | |
| SCHEMBL27010062 | 0.78 | KCNH2 (0.48) | P2RY1KCNH2DRD3CSF1RCDK4 | |
| SCHEMBL21216374 | 0.78 | BCL2L1 (0.46) | P2RY1HRH3KCNH2DRD3KDM4E | |
| SCHEMBL19755625 | 0.78 | HRH3 (0.36) | KMT2AP2RY1HTR1AHRH3KCNH2 | |
| SCHEMBL21361602 | 0.78 | ADRA2A (0.57) | HRH3KCNH2ADRA2AADRA2BADRA2C | |
| SCHEMBL15845886 | 0.78 | CARM1 (0.49) | HTR1AHRH3KCNH2ADRA2AADRA2B | |
| SCHEMBL25465443 | 0.75 | ACACB (0.38) | P2RY1HTR1AHRH3KCNH2ADRA2A | |
| SCHEMBL25463314 | 0.75 | CSF1R (0.41) | P2RY1HTR1AHRH3KCNH2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |