Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26619666 | 0.85 | IRAK4 (0.35) | IRAK4 | |
| SCHEMBL24921073 | 0.85 | — | — | |
| SCHEMBL24315775 | 0.80 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL24995531 | 0.80 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL20727170 | 0.80 | KDM4E (0.37) | HSD11B1 | |
| SCHEMBL18361629 | 0.78 | ALDH1A1 (0.33) | — | |
| SCHEMBL8444083 | 0.78 | DPP4 (0.37) | — | |
| SCHEMBL24315776 | 0.78 | IRAK4 (0.32) | IRAK4 | |
| SCHEMBL24718088 | 0.77 | KDM4E (0.33) | IRAK4 | |
| SCHEMBL25921408 | 0.77 | KDM4E (0.33) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |