Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MPI | P34949 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | UBE2N | P61088 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HEXA | P06865 | 1/20 | 0.40 |
| ▸ | HEXB | P07686 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24317649 | 0.77 | CRBN (0.57) | ALDH1A1TDP1 | |
| SCHEMBL7130966 | 0.76 | ALDH1A1 (0.59) | ALDH1A1HPGDCASP1SMN1; SMN2MPI | |
| SCHEMBL7120833 | 0.75 | POLB (0.60) | ALDH1A1HPGDCASP1SMN1; SMN2MPI | |
| SCHEMBL25123287 | 0.74 | CRBN (0.59) | ALDH1A1TDP1 | |
| SCHEMBL29774558 | 0.72 | CRBN (0.68) | ALDH1A1TDP1 | |
| SCHEMBL22532914 | 0.72 | CRBN (0.68) | ALDH1A1TDP1 | |
| SCHEMBL2175176 | 0.67 | CRBN (0.78) | ALDH1A1TDP1 | |
| SCHEMBL9720971 | 0.66 | HPGD (0.70) | ALDH1A1HPGDCASP1SMN1; SMN2MPI | |
| SCHEMBL6270684 | 0.66 | ALDH1A1 (1.00) | ALDH1A1HPGDCASP1SMN1; SMN2MPI | |
| SCHEMBL29437299 | 0.66 | ALDH1A1 (1.00) | ALDH1A1HPGDCASP1SMN1; SMN2MPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |