Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 12/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD1 | O95696 | 1/20 | 0.33 |
| ▸ | TAF1 | P21675 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24315711 | 0.73 | CYP1B1 (0.40) | CYP1B1ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL24317634 | 0.71 | CYP1B1 (0.41) | CYP1B1ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL29531869 | 0.71 | CYP1B1 (0.41) | CYP1B1ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL29180980 | 0.71 | CYP1B1 (0.52) | CYP1B1ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL24316240 | 0.67 | CYP1B1 (0.41) | CYP1B1ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL22549649 | 0.65 | ALDH1A1 (0.35) | ALDH1A1KDM4ESMN1; SMN2KMT2ALMNA | |
| SCHEMBL30517121 | 0.65 | PKM (0.57) | CYP1B1ALDH1A1POLBKDM4EKMT2A | |
| SCHEMBL12561180 | 0.65 | PKM (0.57) | CYP1B1ALDH1A1POLBKDM4EKMT2A | |
| SCHEMBL10413423 | 0.64 | CYP1B1 (0.78) | CYP1B1ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL30837348 | 0.64 | CYP1B1 (0.78) | CYP1B1ALDH1A1POLBRXFP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |