Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 10/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24315912 | 0.81 | KDM4E (0.34) | ALDH1A1KDM4ELMNAKMT2AMAPT | |
| SCHEMBL24315711 | 0.80 | CYP1B1 (0.40) | CYP1B1ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL24315752 | 0.80 | HDAC8 (0.40) | POLBKDM4EHDAC8LMNAL3MBTL1 | |
| SCHEMBL24315949 | 0.79 | KDM4E (0.32) | KDM4E | |
| SCHEMBL24316089 | 0.78 | MAPT (0.41) | ALDH1A1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24317938 | 0.76 | ALDH1A1 (0.39) | ALDH1A1RXFP1KDM4ELMNAKMT2A | |
| SCHEMBL24317766 | 0.76 | MAPT (0.34) | ALDH1A1RXFP1KDM4EHDAC6MAPT | |
| SCHEMBL24317634 | 0.73 | CYP1B1 (0.41) | CYP1B1ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL29531869 | 0.73 | CYP1B1 (0.41) | CYP1B1ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL24317386 | 0.72 | CYP1B1 (0.52) | CYP1B1ALDH1A1POLBRXFP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |