⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316029 | 0.87 | — | — | |
| SCHEMBL26619401 | 0.83 | SIGMAR1 (0.36) | — | |
| SCHEMBL24317907 | 0.83 | CYP1A2 (0.41) | — | |
| SCHEMBL27010104 | 0.81 | L3MBTL1 (0.38) | — | |
| SCHEMBL24317900 | 0.80 | S1PR1 (0.35) | — | |
| SCHEMBL27010117 | 0.78 | CYP1A2 (0.31) | — | |
| SCHEMBL26619422 | 0.77 | CYP1A2 (0.30) | — | |
| SCHEMBL9927927 | 0.76 | OPRK1 (0.35) | — | |
| SCHEMBL27380316 | 0.76 | OPRK1 (0.35) | — | |
| SCHEMBL27380313 | 0.76 | OPRK1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018118-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C 4 Therapeutics, Inc. (US) | 2024-01-18 | — | — | US | disclosed |
| US-20240018118-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C 4 Therapeutics, Inc. (US) | 2024-01-18 | — | — | US | disclosed |
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |