Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24497941 | 0.80 | MAPT (0.37) | SMN1; SMN2CA12CA1CA9CA2 | |
| SCHEMBL19494263 | 0.80 | HTT (0.38) | SMN1; SMN2CA12CA1CA9CA2 | |
| SCHEMBL19286446 | 0.77 | LMNA (0.38) | SMN1; SMN2CA12CA1CA9CA2 | |
| SCHEMBL19566668 | 0.76 | SMN1; SMN2 (0.36) | SMN1; SMN2LMNAALDH1A1MGLLFAAH | |
| SCHEMBL18745776 | 0.75 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1MGLLFAAHPHGDH | |
| SCHEMBL18744925 | 0.74 | SMN1; SMN2 (0.42) | SMN1; SMN2CA12CA1CA9ALDH1A1 | |
| SCHEMBL22569392 | 0.74 | LMNA (0.35) | SMN1; SMN2LMNA | |
| SCHEMBL24070337 | 0.70 | CA12 (0.41) | SMN1; SMN2CA12CA1CA9CA2 | |
| SCHEMBL22135147 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2CA12CA1CA9CA2 | |
| SCHEMBL19016204 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2CA12CA1CA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081469-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2022-04-21 | — | — | WO | disclosed |