Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24318148 | 0.80 | SMN1; SMN2 (0.40) | HTTTSHRL3MBTL1MGLLSMN1; SMN2 | |
| SCHEMBL24497941 | 0.74 | MAPT (0.37) | HTTTSHRL3MBTL1MGLLSMN1; SMN2 | |
| SCHEMBL8553865 | 0.72 | SMN1; SMN2 (0.45) | HTTTSHRL3MBTL1MGLLSMN1; SMN2 | |
| SCHEMBL8553868 | 0.72 | SMN1; SMN2 (0.45) | HTTTSHRL3MBTL1MGLLSMN1; SMN2 | |
| SCHEMBL20120036 | 0.72 | MAPT (0.43) | HTTTSHRL3MBTL1MGLLSMN1; SMN2 | |
| SCHEMBL19286446 | 0.71 | LMNA (0.38) | HTTL3MBTL1MGLLSMN1; SMN2ALDH1A1 | |
| SCHEMBL5274271 | 0.71 | HTT (0.46) | HTTTSHRL3MBTL1MGLLSMN1; SMN2 | |
| SCHEMBL19566668 | 0.70 | SMN1; SMN2 (0.36) | HTTL3MBTL1MGLLSMN1; SMN2ALDH1A1 | |
| SCHEMBL24313179 | 0.70 | PDK1 (0.36) | HTTPDK1PDK2PDK3LMNA | |
| SCHEMBL21504068 | 0.69 | L3MBTL1 (0.42) | HTTTSHRL3MBTL1MGLLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3235816-B1 | 2-MORPHOLIN-4,6-DISUBSTITUTED PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2020-02-12 | — | — | EP | disclosed |
| EP-3235816-A1 | 2-MORPHOLIN-4,6-DISUBSTITUTED PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2017-10-25 | — | — | EP | disclosed |