Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.33 |
| ▸ | ABAT | P80404 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | IAPP | P10997 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721174 | 0.83 | IGF1R (0.39) | IGF1RALOX15 | |
| SCHEMBL4190007 | 0.82 | BACE1 (0.40) | KDM4EALDH1A1ALOX5IGF1RALOX15 | |
| SCHEMBL722594 | 0.82 | IGF1R (0.36) | ALOX5ADRB2ADRB1ADRB3IGF1R | |
| SCHEMBL11296369 | 0.82 | NAT1 (0.34) | — | |
| SCHEMBL6473875 | 0.81 | GRIN2D (0.41) | KDM4EPTGS2ALDH1A1TDP1ALOX15 | |
| SCHEMBL11300811 | 0.81 | IGF1R (0.35) | ALOX5IGF1RALOX15 | |
| SCHEMBL11299423 | 0.81 | MAOA (0.44) | RAB9AALDH1A1TDP1MAOAMAOB | |
| SCHEMBL11300806 | 0.80 | AKR1C3 (0.36) | ALDH1A1 | |
| SCHEMBL11295519 | 0.79 | HTR2B (0.39) | IGF1RALOX15MAOB | |
| SCHEMBL1355901 | 0.79 | CYP4A11 (0.47) | KDM4ERAB9AALDH1A1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364966-A1 | Process for preparation of 3-(2-hydroxy-5-substituted phenyl)-3-phenylpropylamines, intermediates for making hydroxytolterodine | LEK Pharmaceuticals d.d. (SI) | 2011-09-14 | — | — | EP | disclosed |