Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17753773 | 0.88 | ACHE (0.47) | ACHECHRM5ADRA2CNOS3NOS1 | |
| SCHEMBL23267306 | 0.85 | CHRM5 (0.38) | NCF1ACHECHRM5ADRA2CCACNA2D1 | |
| SCHEMBL13874610 | 0.84 | ACHE (0.59) | ACHECHRM5ADRA2CNOS3NOS1 | |
| SCHEMBL3439900 | 0.82 | ACHE (0.62) | ACHECHRM5ADRA2C | |
| SCHEMBL24319371 | 0.82 | NCF1 (0.37) | NCF1ACHECHRM5ADRA2CCACNA2D1 | |
| SCHEMBL24319476 | 0.81 | NCF1 (0.50) | NCF1ACHECHRM5ADRA2CCACNA2D1 | |
| SCHEMBL23173902 | 0.81 | NCF1 (0.54) | NCF1ACHECHRM5ADRA2CCACNA2D1 | |
| SCHEMBL25571706 | 0.81 | NCF1 (0.54) | NCF1ACHECHRM5ADRA2CCACNA2D1 | |
| SCHEMBL46703 | 0.81 | L3MBTL3 (0.42) | NCF1KDM4EALDH1A1 | |
| SCHEMBL25489110 | 0.80 | ACHE (0.38) | ACHECHRM5ADRA2CNOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |