⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319358 | 1.00 | — | — | |
| SCHEMBL24319451 | 0.82 | — | — | |
| SCHEMBL26042820 | 0.79 | KDM1A (0.35) | — | |
| SCHEMBL17623739 | 0.74 | — | — | |
| SCHEMBL25090055 | 0.74 | — | — | |
| SCHEMBL8260137 | 0.74 | — | — | |
| SCHEMBL22564972 | 0.71 | SIGMAR1 (0.35) | — | |
| SCHEMBL22703776 | 0.70 | ACHE (0.35) | — | |
| SCHEMBL24202744 | 0.70 | GBA1 (0.31) | — | |
| SCHEMBL5188366 | 0.70 | ALOX15 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023066350-A1 | CRBN E3 LIGASE LIGAND COMPOUND, PROTEIN DEGRADING AGENT DEVELOPED ON THE BASIS OF LIGAND COMPOUND, AND THEIR APPLICATIONS | 标新生物医药科技(上海)有限公司 | 2023-04-27 | — | — | WO | disclosed |
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |