Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 11/20 | 0.36 |
| ▸ | DRD2 | P14416 | 8/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27634533 | 0.88 | GBA2 (0.42) | GBA1 | |
| SCHEMBL23828685 | 0.84 | CXCR4 (0.33) | — | |
| SCHEMBL15363092 | 0.84 | GBA1 (0.45) | GBA1 | |
| SCHEMBL14767903 | 0.82 | SIGMAR1 (0.33) | — | |
| SCHEMBL25530401 | 0.82 | SIGMAR1 (0.33) | — | |
| SCHEMBL15787847 | 0.81 | — | — | |
| SCHEMBL26855304 | 0.81 | — | — | |
| SCHEMBL16111358 | 0.79 | GNAI3 (0.39) | GBA1HTR1ADRD2CYP2D6TSHR | |
| SCHEMBL20172082 | 0.78 | GBA1 (0.36) | GBA1HTR1ADRD2CYP2D6TSHR | |
| SCHEMBL17194448 | 0.78 | GBA1 (0.45) | GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567334-B2 | Quinolone derivatives as fibroblast growth factor receptor inhibitors | PRINCIPIA BIOPHARMA, INC. (US) | 2017-02-14 | — | — | US | disclosed |