Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319167 | 1.00 | SIGMAR1 (0.42) | SIGMAR1NCF1SCN1ASCN4ASCN7A | |
| SCHEMBL24319338 | 0.83 | SCN1A (0.46) | SIGMAR1NCF1SCN1ASCN4ASCN7A | |
| SCHEMBL18202953 | 0.73 | SIGMAR1 (0.47) | SIGMAR1SCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL20320096 | 0.73 | SLC6A4 (0.34) | KCNH2 | |
| SCHEMBL18685394 | 0.73 | SLC6A4 (0.34) | KCNH2 | |
| SCHEMBL24319185 | 0.72 | NCF1 (0.39) | SIGMAR1NCF1SCN1ASCN4ASCN7A | |
| SCHEMBL25666707 | 0.72 | NCF1 (0.42) | SIGMAR1NCF1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL24319646 | 0.72 | NCF1 (0.42) | SIGMAR1NCF1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL24319165 | 0.72 | NCF1 (0.42) | SIGMAR1NCF1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL25666713 | 0.72 | NCF1 (0.42) | SIGMAR1NCF1CACNA2D1CACNA1BCACNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |