SCHEMBL24319185

SCHEMBL24319185

CN1CCC(CN2CCC(C3(C)CC3)CC2)CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NCF1 P14598 1/20 0.39
ACHE P22303 1/20 0.39
CACNA2D1 P54289 1/20 0.36
CACNA1B Q00975 1/20 0.36
CACNB1 Q02641 1/20 0.36
CACNA1C Q13936 1/20 0.36
CHRM5 P08912 1/20 0.35
ADRA2C P18825 1/20 0.35
SCN1A P35498 1/20 0.34
SCN4A P35499 1/20 0.34
SCN7A Q01118 1/20 0.34
KCNH2 Q12809 1/20 0.34
SCN5A Q14524 1/20 0.34
SCN9A Q15858 1/20 0.34
SCN2A Q99250 1/20 0.34
SCN3A Q9NY46 1/20 0.34
SCN11A Q9UI33 1/20 0.34
SCN8A Q9UQD0 1/20 0.34
SCN10A Q9Y5Y9 1/20 0.34
SIGMAR1 Q99720 4/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24319338 0.86 SCN1A (0.46) NCF1ACHECACNA2D1CACNA1BCACNB1
SCHEMBL24319509 0.86 ACHE (0.35) ACHECHRM5ADRA2CSCN1ASCN4A
SCHEMBL17033031 0.82 NCF1 (0.37) NCF1KCNH2OPRM1
SCHEMBL24319174 0.81 ACHE (0.38) ACHECACNA2D1CACNA1BCACNB1CHRM5
SCHEMBL24832947 0.79 NCF1 (0.43) NCF1ACHECACNA2D1CACNA1BCACNB1
SCHEMBL24319476 0.78 NCF1 (0.50) NCF1ACHECACNA2D1CACNA1BCACNB1
SCHEMBL23173902 0.78 NCF1 (0.54) NCF1ACHECACNA2D1CACNA1BCACNB1
SCHEMBL25571706 0.78 NCF1 (0.54) NCF1ACHECACNA2D1CACNA1BCACNB1
SCHEMBL25074351 0.77 GNAI3 (0.50) NCF1ACHECACNA2D1CACNA1BCACNB1
SCHEMBL23816392 0.76 NCF1 (0.41) NCF1ACHECACNA2D1CACNA1BCACNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022047145-A1 RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2022-03-03 WO disclosed