Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 10/20 | 0.47 |
| ▸ | CA2 | P00918 | 10/20 | 0.47 |
| ▸ | CA12 | O43570 | 6/20 | 0.47 |
| ▸ | CA4 | P22748 | 3/20 | 0.47 |
| ▸ | CA5A | P35218 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ATF4 | P18848 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24323095 | 0.90 | ATF4 (0.47) | ATF4LMNAMAPT | |
| SCHEMBL19577449 | 0.90 | ATF4 (0.47) | ATF4LMNAMAPT | |
| SCHEMBL24322893 | 0.84 | ALDH1A1 (0.48) | ALDH1A1CA1CA2CA12CA4 | |
| SCHEMBL19577477 | 0.83 | ATF4 (0.53) | ALDH1A1CA1CA2CA12CA4 | |
| SCHEMBL24323038 | 0.82 | ATF4 (0.48) | ATF4 | |
| SCHEMBL24324573 | 0.82 | ATF4 (0.47) | ATF4 | |
| SCHEMBL24323279 | 0.81 | ATF4 (0.47) | ALDH1A1ATF4MAPTSMN1; SMN2 | |
| SCHEMBL24324336 | 0.81 | ATF4 (0.44) | ATF4 | |
| SCHEMBL24323329 | 0.80 | ATF4 (0.46) | ALDH1A1POLBATF4MAPT | |
| SCHEMBL19577479 | 0.80 | ATF4 (0.47) | ALDH1A1CA1CA2CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |