Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ATF4 | P18848 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19577396 | 0.93 | PPARD (0.56) | PPARDPOLBKMT2AMAPTATF4 | |
| SCHEMBL19577397 | 0.87 | ATF4 (0.62) | DRD2DRD4DRD3KDM4EKMT2A | |
| SCHEMBL24322995 | 0.85 | PPARD (0.58) | PPARDPOLBDRD2DRD4DRD3 | |
| SCHEMBL19577393 | 0.82 | ATF4 (0.56) | PPARDKDM4EATF4TP53 | |
| SCHEMBL19555682 | 0.81 | ATF4 (0.70) | KDM4EKMT2AATF4MEN1NPC1 | |
| SCHEMBL19577394 | 0.80 | ATF4 (0.57) | POLBMAPK1GAAMAPTATF4 | |
| SCHEMBL24116911 | 0.80 | ATF4 (0.56) | PPARDKDM4EATF4 | |
| SCHEMBL19569418 | 0.79 | ATF4 (0.74) | POLBKMT2AMAPK1GAAMAPT | |
| SCHEMBL30025592 | 0.79 | ATF4 (0.74) | POLBKMT2AMAPK1GAAMAPT | |
| SCHEMBL22395386 | 0.78 | ATF4 (0.61) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |