Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24323107 | 0.92 | NPC1 (0.52) | PPARDPOLBKDM4EKMT2ANPC1 | |
| SCHEMBL24324540 | 0.88 | NPC1 (0.58) | DRD2DRD4DRD3KDM4EKMT2A | |
| SCHEMBL24322982 | 0.86 | NPC1 (0.43) | PPARDPOLBKDM4EKMT2ANPC1 | |
| SCHEMBL24323517 | 0.85 | PPARD (0.59) | PPARDPOLBDRD2DRD4DRD3 | |
| SCHEMBL19577396 | 0.81 | PPARD (0.56) | PPARDPOLBKMT2ANPC1MAPT | |
| SCHEMBL24324190 | 0.79 | ATF4 (0.52) | DRD2DRD4DRD3KDM4EKMT2A | |
| SCHEMBL21116634 | 0.76 | PPARD (0.55) | PPARDPOLBKMT2ANPC1GAA | |
| SCHEMBL22040865 | 0.74 | PPARD (1.00) | PPARDPOLBDRD2DRD4KDM4E | |
| SCHEMBL26382364 | 0.74 | PPARD (0.83) | PPARDPOLBDRD2DRD4DRD3 | |
| SCHEMBL19577397 | 0.73 | ATF4 (0.62) | DRD2DRD4DRD3KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |