Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 11/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.54 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23851083 | 0.89 | CYP19A1 (0.57) | ESR1CYP19A1ESR2CYP3A4CYP1A2 | |
| SCHEMBL23851081 | 0.89 | CYP19A1 (0.57) | ESR1CYP19A1ESR2CYP3A4CYP1A2 | |
| SCHEMBL15562738 | 0.86 | CA2 (0.44) | CYP1A2MAPK14MEN1ALDH1A1LMNA | |
| SCHEMBL16387646 | 0.82 | CA2 (0.41) | MAPK14ALDH1A1LMNA | |
| SCHEMBL16387661 | 0.82 | MAPK14 (0.39) | CYP1A2MAPK14MEN1ALDH1A1LMNA | |
| SCHEMBL16387648 | 0.82 | CA2 (0.41) | MAPK14ALDH1A1LMNA | |
| SCHEMBL16387672 | 0.82 | MAPK14 (0.39) | CYP1A2MAPK14MEN1ALDH1A1LMNA | |
| SCHEMBL16342498 | 0.82 | MAPK14 (0.39) | CYP1A2MAPK14MEN1ALDH1A1LMNA | |
| SCHEMBL16342568 | 0.82 | CA2 (0.41) | MAPK14ALDH1A1LMNA | |
| SCHEMBL5727139 | 0.81 | ESR1 (0.51) | ESR1CYP19A1ESR2CYP3A4MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220089600-A1 | TGFß INHIBITOR AND PRODRUGS | FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) (ES) | 2022-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089600-A1 | TGFß INHIBITOR AND PRODRUGS | TGFB1, TGFBR1, TGFBR2 | ESR1 2521/4885CYP19A1 557/4885ESR2 876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.