Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 2/20 | 0.42 |
| ▸ | PDE9A | O76083 | 2/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24323519 | 0.90 | PANK3 (0.41) | PANK3PDE9AEP300PARP1OPRM1 | |
| SCHEMBL28024107 | 0.83 | PANK3 (0.49) | PANK3PARP1AREGLN2CTSL | |
| SCHEMBL24324113 | 0.82 | PANK3 (0.39) | PANK3PARP1OPRM1OPRL1EGLN2 | |
| SCHEMBL153675 | 0.80 | ALDH1A1 (0.48) | PANK3PARP1ARCTSK | |
| SCHEMBL151146 | 0.79 | PANK3 (0.47) | PANK3PARP1CTSLCTSSCTSK | |
| SCHEMBL150176 | 0.78 | ALDH1A1 (0.47) | PANK3PARP1ARCTSK | |
| SCHEMBL139436 | 0.78 | ALDH1A1 (0.47) | PANK3PARP1ARCTSK | |
| SCHEMBL24989603 | 0.75 | CHRNB2 (0.50) | PANK3 | |
| SCHEMBL154604 | 0.75 | KDM4E (0.47) | PANK3CTSSCTSKCHEK1 | |
| SCHEMBL151294 | 0.73 | NCF1 (0.44) | PANK3CTSLCTSSCTSKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225765-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| CN-116601158-A | Modulators of cystic fibrosis transmembrane conductance regulator | 弗特克斯药品有限公司 | 2023-08-15 | — | — | CN | disclosed |
| WO-2022076622-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |
| WO-2022076622-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |