SCHEMBL24323949

SCHEMBL24323949

CC1(C)CCN(c2cnc(C=O)nc2)CC1

nearest known ligand 0.33

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KCNQ2 O43526 1/20 0.33
LNPEP Q9UIQ6 1/20 0.33
ALDH1A1 P00352 5/20 0.33
MAPT P10636 1/20 0.33
TDP1 Q9NUW8 1/20 0.32
TRIM24 O15164 1/20 0.31
TRIM33 Q9UPN9 1/20 0.31
EP300 Q09472 1/20 0.30
PDE9A O76083 1/20 0.30
CHRNB2 P17787 1/20 0.30
CHRNA4 P43681 1/20 0.30
KDM4E B2RXH2 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
ACACB O00763 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24323811 0.90 SIGMAR1 (0.33) LNPEPTDP1CHRNB2CHRNA4ACACB
SCHEMBL24323937 0.82 TDP1 (0.30) TDP1
SCHEMBL15264409 0.80 TRIM24 (0.48) ALDH1A1MAPTTRIM24TRIM33CHRNB2
SCHEMBL24323360 0.75 POLB (0.47) ALDH1A1MAPTTDP1KDM4ESMN1; SMN2
SCHEMBL24323948 0.72 PANK3 (0.42) LNPEPEP300PDE9A
SCHEMBL7989572 0.71 TRIM24 (0.63) ALDH1A1TRIM24TRIM33KDM4ESMN1; SMN2
SCHEMBL17207204 0.70 ELANE (0.41) KCNQ2ALDH1A1MAPTCHRNB2CHRNA4
SCHEMBL17054793 0.69 CHRNB2 (0.40) CHRNB2CHRNA4
SCHEMBL5647111 0.69 CHRNB2 (0.40) KCNQ2LNPEPMAPTEP300CHRNB2
SCHEMBL24324476 0.68 SIGMAR1 (0.36) KCNQ2CHRNB2CHRNA4ACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4225765-A2 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2023-08-16 EP disclosed
CN-116601158-A Modulators of cystic fibrosis transmembrane conductance regulator 弗特克斯药品有限公司 2023-08-15 CN disclosed
WO-2022076622-A2 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-14 WO disclosed
WO-2022076622-A2 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-14 WO disclosed