Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 2/20 | 0.35 |
| ▸ | LDHB | P07195 | 2/20 | 0.35 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.34 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.34 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 2/20 | 0.31 |
| ▸ | PPM1D | O15297 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24298775 | 1.00 | LDHA (0.35) | LDHALDHBGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL24323721 | 0.99 | LDHA (0.36) | LDHALDHBGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL24323797 | 0.96 | LDHA (0.32) | LDHALDHBKDM4C | |
| SCHEMBL26569626 | 0.90 | — | — | |
| SCHEMBL24298776 | 0.89 | — | — | |
| SCHEMBL26572133 | 0.89 | GPR84 (0.37) | KDM4CPTGER1 | |
| SCHEMBL24323694 | 0.88 | LDHA (0.31) | LDHALDHB | |
| SCHEMBL24324641 | 0.87 | CYP1A2 (0.31) | LDHALDHB | |
| SCHEMBL26576986 | 0.87 | LDHA (0.35) | LDHALDHBEPHX1 | |
| SCHEMBL24298880 | 0.86 | MAPK8 (0.33) | CDK1CDK2AKT1METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076622-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |