Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.46 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631576 | 0.81 | ATF4 (0.56) | ATF4NPSR1KMT2ANPC1ALDH1A1 | |
| SCHEMBL21116592 | 0.75 | KMT2A (0.47) | ATF4NPSR1KMT2ANPC1ALDH1A1 | |
| SCHEMBL24323152 | 0.72 | ATF4 (0.51) | ATF4KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL21116380 | 0.72 | NPC1 (0.53) | ATF4KMT2ANPC1ALDH1A1TSHR | |
| SCHEMBL21116984 | 0.71 | DRD2 (0.44) | ATF4NPSR1KMT2ANPC1ALDH1A1 | |
| SCHEMBL23182883 | 0.71 | ATF4 (0.55) | ATF4NPSR1KMT2ANPC1ALDH1A1 | |
| SCHEMBL20631568 | 0.70 | ATF4 (0.52) | ATF4NPSR1KMT2ANPC1ALDH1A1 | |
| SCHEMBL19705237 | 0.70 | SMN1; SMN2 (0.67) | ATF4KMT2ANPC1ALDH1A1MEN1 | |
| SCHEMBL23182604 | 0.69 | KMT2A (0.54) | KMT2ANPC1MEN1SMN1; SMN2KDM4E | |
| SCHEMBL28619865 | 0.69 | KMT2A (0.57) | KMT2ANPC1ALDH1A1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |