Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | ATF4 | P18848 | 8/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24323107 | 0.96 | NPC1 (0.52) | NPC1ATF4KDM4ELMNAMAPT | |
| SCHEMBL24324190 | 0.91 | ATF4 (0.52) | NPC1ATF4KDM4ELMNADRD2 | |
| SCHEMBL24322995 | 0.88 | PPARD (0.58) | NPC1KDM4ELMNAMAPTDRD2 | |
| SCHEMBL24322982 | 0.87 | NPC1 (0.43) | NPC1ATF4KDM4ELMNAMAPT | |
| SCHEMBL19577397 | 0.85 | ATF4 (0.62) | NPC1ATF4KDM4ELMNAMAPT | |
| SCHEMBL19569414 | 0.80 | ATF4 (0.75) | NPC1ATF4L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL21116380 | 0.79 | NPC1 (0.53) | NPC1ATF4KDM4ELMNAMAPT | |
| SCHEMBL19555682 | 0.79 | ATF4 (0.70) | NPC1ATF4KDM4EKMT2AATM | |
| SCHEMBL19569416 | 0.78 | ATF4 (0.86) | NPC1ATF4KDM4ELMNAMAPT | |
| SCHEMBL19577396 | 0.76 | PPARD (0.56) | NPC1ATF4LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |