Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ATF4 | P18848 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24324540 | 0.96 | NPC1 (0.58) | NPC1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL24322995 | 0.92 | PPARD (0.58) | NPC1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL24322982 | 0.89 | NPC1 (0.43) | NPC1KMT2AMEN1KDM4EHDAC1 | |
| SCHEMBL24324190 | 0.86 | ATF4 (0.52) | NPC1KMT2AKDM4ELMNAGAA | |
| SCHEMBL19577397 | 0.80 | ATF4 (0.62) | NPC1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL24323517 | 0.76 | PPARD (0.59) | NPC1KMT2AMEN1KDM4EGAA | |
| SCHEMBL21116380 | 0.74 | NPC1 (0.53) | NPC1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL19555682 | 0.73 | ATF4 (0.70) | NPC1KMT2AMEN1KDM4EATF4 | |
| SCHEMBL19569414 | 0.73 | ATF4 (0.75) | NPC1KMT2AMEN1ATF4ALDH1A1 | |
| SCHEMBL24323244 | 0.73 | ALDH1A1 (0.47) | NPC1KMT2AMEN1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |