Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ATF4 | P18848 | 9/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24116936 | 0.86 | ATF4 (0.46) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL21116646 | 0.86 | ATF4 (0.46) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL24323059 | 0.86 | GAA (0.53) | ALDH1A1ATF4MEN1HTTKMT2A | |
| SCHEMBL24116960 | 0.85 | TAOK1 (0.51) | ALDH1A1ATF4GRIN1GRIN2B | |
| SCHEMBL21117004 | 0.85 | KMT2A (0.47) | ALDH1A1ATF4RAB9AHPGDMEN1 | |
| SCHEMBL24324507 | 0.85 | LMNA (0.49) | ALDH1A1ATF4HPGDMEN1HTT | |
| SCHEMBL24322876 | 0.85 | ATF4 (0.45) | ALDH1A1ATF4HTT | |
| SCHEMBL21116455 | 0.85 | HPGD (0.54) | ALDH1A1ATF4RAB9AHPGDGRIN1 | |
| SCHEMBL24116904 | 0.85 | KDM4E (0.50) | ALDH1A1ATF4RAB9AHPGDGRIN1 | |
| SCHEMBL21116456 | 0.85 | MEN1 (0.49) | ALDH1A1ATF4MEN1PPARGHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |