Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 7/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.41 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24324507 | 0.94 | LMNA (0.49) | ATF4HTTALDH1A1SGMS1LMNA | |
| SCHEMBL21116606 | 0.93 | ATF4 (0.45) | ATF4HTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24323059 | 0.92 | GAA (0.53) | ATF4HTTALDH1A1LMNAGAA | |
| SCHEMBL24116960 | 0.92 | TAOK1 (0.51) | ATF4ALDH1A1SMN1; SMN2TAOK1TAOK3 | |
| SCHEMBL21117004 | 0.92 | KMT2A (0.47) | ATF4HTTALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL21116655 | 0.91 | TRPV1 (0.44) | ATF4ALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL21116605 | 0.91 | ADAMTS5 (0.43) | ATF4ALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL24116642 | 0.90 | ALDH1A1 (0.47) | ATF4ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL21116635 | 0.90 | L3MBTL1 (0.44) | ATF4ALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL21116656 | 0.89 | HTT (0.52) | ATF4HTTALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |